Different aspects of health are more interconnected than patients may realize. And yet, research is still working towards a clear understanding of these connections. While studies suggest various lifestyle factors can influence overall health, the relationship between exercise and the brain is still uncertain (Nichols et al., 2024).
Despite this uncertainty, gaining a better understanding of this connection is particularly important for older patients. It's why Creyos was used to measure cognitive outcomes in the Brain and Body Study. As patients age into their senior years, they become more vulnerable to cognitive decline (Deary et al., 2009). If exercise does have a positive impact on brain health, then consistent physical activity has the potential to promote healthy cognitive aging and help protect against cognitive decline (Christie et al., 2017).
This article explores the relationship between exercise and the brain by examining various types of workouts and how they may affect cognitive and mental health. We also explore ways to measure the impact of exercise on brain health with computerized cognitive tests to determine which lifestyle interventions can truly improve cognition.
While research has long established that exercise is of great benefit for physiological health, (Posadzki et al., 2020) the results are less clear when pinpointing exactly which aspects of brain health are affected. A review of 24 meta-analyses with a focus on the relationship between physical exercise and cognition reported that stronger causal evidence is required before we can definitively conclude that exercise improves our brain health (Nature 2023).
That's why it's vital that more research is conducted, so that patients understand the ways in which exercise can help reduce the symptoms of cognitive decline or if other forms of preventive treatment might also be useful.
Read More: How to Prevent Dementia: 12 Modifiable Risk Factors
Educating patients on how exercise affects their health is a routine part of physical and cognitive health check ups. By discussing the importance of various health strategies, primary care providers (PCPs) can help patients form realistic expectations on how lifestyle factors impact cognition.
When it comes to preventive care, studies suggest that exercise has health benefits for the brain and cognition throughout life (Hillman et al., 2008). The research concludes that aerobic exercise and fitness training helps improve neurogenesis, develop blood vessels, and form synaptic connections in the brain.
Because many interconnected factors may affect brain health, it’s difficult to isolate precisely how exercise impacts cognitive and psychological health. Genetic and environmental factors can also shape a patient’s cognitive and mental health, but lifestyle factors are considered “modifiable risk factors” that are within a patient’s ability to influence. So there are concerted efforts within healthcare to encourage exercise as a preventive strategy in the context of cardiovascular, neurodegenerative, mental health, and chronic conditions (Thompson et al., 2020).
More research is required to determine exactly how physical activity can benefit the brain.
While exercise is one of the 12 modifiable risk factors for dementia, research suggests that the effects of physical activity on dementia prevention and management isn't as clear cut as it may seem. When it comes to patients with dementia who need to manage the disease, a systematic review on exercise training and older adults with different kinds of dementia indicates that the findings of 48 different studies aren't conclusive (Balbim et al., 2022).
While exercise did benefit the cognitive function of older adults with dementia, the review suggests that more research needs to be conducted, especially when it comes to determining if the effects of exercise differ depending on the type of dementia a patient has. Similarly, another review suggests that exercise as a form of dementia prevention varies depending on the individual (Mullers et al., 2019). As such, even though exercise is a modifiable risk factor for dementia, its efficacy may depend on the type of dementia a patient has and whether that patient responds well to exercise in the first place.
Exercise and staying physically healthy can be effective methods for managing mental health conditions like depression, stress, and anxiety. Research indicates that physical activity reduces inflammation, which can contribute to better health outcomes for patients suffering from mood disorders.
However, exercise may not be the most optimal intervention for every patient. A study on the effects of exercise during the COVID-19 lockdowns suggests that people with lower tolerance for feelings of anxiety and uncertainty can become addicted to exercise under specific conditions (Mikkelsen et al., 2017). While exercise isn't meant to be a cure-all for mental health disorders, it can serve as a viable supplementary option alongside traditional treatments, offering a non-pharmacological approach to enhancing overall mental wellness.
Interestingly, the Brain and Body Study found that video gaming during the COVID-19 lockdown generally had a positive influence on participants’ wellbeing and mental health (Barr & Copeland-Stewart, 2021).
Some of the attributes of video games that potentially contributed to these results included:
In addition to the physical nature of exercise, the cognitive and mental health benefits may be similarly tied to the above characteristics, shared by video games. This research highlights how different interventions may be appropriate to support brain health depending on the individual and their context.
Can chronic pain negatively impact cognition over time? A review on chronic pain in the elderly suggests that this is a possibility, with evidence that indicates pain can aggravate memory loss for Alzheimer's disease patients or trigger motor symptoms among those suffering from Parksinson's disease (Dagnino & Campos, 2022).
But whether managing pain through exercise can actually help reduce or slow the effects of neurodegenerative diseases is still uncertain. Even exercise as a tool to manage chronic neuropathic pain has inconsistent results—as indicated in a review, aerobic exercise training led to reductions in pain interference but had no effect on pain intensity (Leitzelar & Koltyn, 2021). In other words, exercise may reduce some, but not all, pain measures.
In contrast, a systematic review on the effects of exercise on individuals with musculoskeletal pain is more positive, but it also acknowledges that more research needs to be done on whether pain reduction has an effect on patient outcomes and quality of life (Cicuttini et al., 2022). Exercise as a form of pain management may be able to help reduce certain chronic pains in older patients with cognitive conditions, and potentially support mental and cognitive wellbeing at the same time. Of course, more detailed research is needed into the complex relationship between the brain and the body.
The connection between cardiovascular health and physical activity is thoroughly documented. In addition, hypertension, caused by high blood pressure damaging blood vessels, can lead to cognitive impairment and dementia (Canavan & Donnell, 2022).
As such, hypertension is a modifiable risk factor for dementia which can be reduced through lifestyle changes and treatments targeted at improving cardiovascular health, such as exercise.
Healthcare providers have to determine on a per-patient basis whether medications, such as antihypertensive treatments for cardiovascular disease, or lifestyle changes, or a combination of both are appropriate for a patient. While more research is needed into precisely what kind of cardiovascular treatment is optimal for brain health, there is potential benefit to introducing exercise for patients with comorbid heart and brain health concerns.
Type 2 diabetes is another risk factor for dementia, although its association with cognitive dysfunction is less well-known. Exercise as a form of prevention and treatment for diabetes patients, alongside dietary restrictions, can be an effective method of glycemic control by enhancing insulin sensitivity and improving glucose uptake, which reduces the risk of insulin resistance.
These benefits extend to cognitive function, as consistent exercise helps prevent elevated blood sugar levels which can damage brain blood vessels and nerves, leading to cognitive impairment (Vijayakumar et al., 2012). However, more research needs to be done when considering other factors alongside exercise, such as diet, medication, and genetics.
While physical activity is beneficial for physiological health, there is also evidence that certain exercise interventions may support cognitive and mental health—particularly in older adults.
Often referred to as "cardio," aerobic exercise improves cardiovascular endurance and fitness. It involves continuous, rhythmic activities like walking, running, cycling, swimming, and dancing.
But does it affect the brain? A meta-analysis indicates that aerobic exercise is directly tied to hippocampal and gray matter volume (Firth et al., 2018). However, the meta-analysis found no evidence that exercise changes total hippocampal volume, only that it helps retain left hippocampal volume in healthy older adults. The review also notes that there was some risk of bias among included studies, which means more research is required to better understand how aerobic exercise and brain health are connected.
Also known as strength training, weight training is performed with a specific number of sets and repetitions, where the patient lifts, lowers, or holds a weight against gravity. Typically, regular weight training can help build and maintain muscle mass, but there may also be associations between exercise, processing speed, and executive function.
While there is some overlap between resistance training and weight training, this kind of exercise is designed to improve muscle strength and endurance by working against an external force of resistance. This external force can come from various sources, including free weights (dumbbells and barbells), resistance bands, weight machines, or even body weight.
Like aerobic exercise, resistance training may be linked to hippocampus volume and brain plasticity. A study of hippocampal plasticity and resistance training for older adults vulnerable to Alzheimer's disease (AD) shows that frequent resistance exercise helped prevent hippocampal atrophy (Broadhouse et al., 2020). The results suggest resistance training can act as a kind of neuroprotection, helping to prevent atrophy in brain areas vulnerable to AD. More research is needed to find out how long-lived this neuroprotection actually is, and whether it's significant enough to delay cognitive decline.
The study examined the cognitive performance of participants aged 85 to 99 years old and found that those who included weight training in their workouts saw improvements in their cognitive test scores (Ho et al., 2023). In this case, it should be noted that performing the actual weight training exercises was self-reported by participants, lending them a degree of subjectivity.
Other meta-reviews have supported that weight training and resistance training show positive effects on cognition, but more research is needed to further isolate the mechanisms at play (Landrigan et al., 2019).
While it can be challenging to talk to patients about cognitive health care, linking the possible benefits of exercise to brain health is one way to introduce the topic. How a PCP guides the conversation depends on their individual practice, but there are a few general questions that patients may have. These questions may include:
With more research into the connection between the body and brain, exercise has the potential to offer a range of cognitive and mental health benefits in the following areas:
While it's possible that exercise may be able to reshape the brain, research in this area is still underway to determine the concrete connections (Augusto-Oliveira, 2023). Physical wellness may be used as a form of brain care in certain circumstances, but whether exercise can actually rewire the brain, and to what degree, still requires more research.
The exact nature of how each type of exercise affects the brain still needs to be determined. As such, there is no optimal exercise for brain health at the moment. However, various exercises have the potential to benefit the brain in different ways. Resistance exercises may be able to preserve brain volume (Neves et al., 2023), aerobic exercises may be able to improve cognitive function (Riganello et al., 2023), and yoga may have strong mental health benefits (Chobe et al., 2020).
Although it may seem like a sedentary lifestyle can negatively affect brain health, research is still unclear about this relationship. A systematic review of sedentary behaviors and its impact on cognitive decline in older adults showed that there is still a lack of clarity in this area—for example, it can be difficult to determine if sedentary time has an effect independent from exercise (Olanrewaju et al., 2020). Similarly, a study on how sedentary time affects the cognition of adolescents found that their planning skills were linked with sedentary time, while memory and executive functions remained the same (Van Oeckel et al., 2024).
Without the right tools, PCPs can't accurately assess changes in a patient's brain function and mental well-being, and are forced to rely on more subjective measures instead. But there are cognitive healthcare solutions that can more precisely and objectively track how exercise and lifestyle interventions affect a patient's cognitive health.
Using scientifically-backed technology, Creyos offers a sophisticated platform for computerized, standardized cognitive function tests. Creyos allows PCPs to test cognitive performance through online cognitive tasks, enabling users to monitor changes in memory, attention, and other cognitive domains resulting from regular physical activity. PCPs can even track a patient’s psychological symptoms through self-report behavioral health questionnaires, such as the PHQ-9 and GAD-7, allowing PCPs to gather more accurate diagnostic and longitudinal data and deliver a patient-centered approach to care.
With Creyos, the complex relationship between exercise and the brain can be monitored with greater detail and insight, leading to more informed decisions and personalized approaches to enhancing cognitive well-being while also playing a part in whole person care.
Here are some additional studies where Creyos was used to measure the connection between exercise and cognition:
While more research needs to be done to determine the exact ways in which exercise may benefit cognitive function and mental health, the positive effects of physical activity on brain and body health are firmly established.
Given the complex links between physical activity and brain health, exercise is not a one-size-fits all intervention. For the patients who can benefit, a personalized and balanced exercise routine that includes aerobic, weight training, and resistance training—alongside tools like Creyos to capture objective measurements—has the potential to help some patients improve their brain health.
Want to know about future research on the connection between exercise, video gaming, and the brain? Keep a close eye on the upcoming Brain and Body Study. The study invited thousands of participants from around the world to take part in a variety of engaging, scientifically-validated online games. The results will help neuroscientists pinpoint the exact ties between physical health and brain health, while also giving all participants further insight into how their own brain works.
The Brain & Body Study looked at: