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Digitized Cognitive Testing for Precise Neurological Care

Obtain clinically precise cognitive insights—without lengthy neuropsychological evaluations. Creyos is the digital cognitive assessment platform neurologists trust to screen, monitor, and support diagnosis of brain health conditions—delivering fast, domain-specific information that enhance clinical decisions and improve patient outcomes.

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Trusted by Leading Neurology Practices

Backed by Science. Built for Clinical Precision

Creyos is grounded in over 35 years of neuroscience research, developed under the leadership of world-renowned cognitive neuroscientist Professor Adrian Owen.

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Validated by Over 400 Peer Reviewed Studies

Published in respected journals like Nature, Neuron, and the Journal of Neurology, Creyos has been validated by researchers as a reliable solution for measuring cognitive function.

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Backed by Normative Data From Over 85,000 Participants

Creyos benchmarks each patient’s cognitive performance against one of the world’s largest normative databases of children and adults–enabling age and gender-adjusted insights you can trust. 

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Results Comparable to Neuropsychological Assessment

Creyos cognitive assessments have been shown to correlate with gold-standard neuropsychological evaluation in published research, offering a faster, scalable alternative for clinical practice.

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January, 2025

An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: A randomized controlled trial

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Brain Imaging and Behavior

September, 2024

Can an online battery match in-person cognitive testing in providing information about age-related cortical morphology?

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March, 2020

Concussion-related deficits in the general population predict impairments in varsity footballers

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December, 2012

Fractionating Human Intelligence

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A Better Way to Detect, Diagnose, and Plan

Fast, Digital Cognitive Testing

Online screener, assessment, and questionnaires—clinically validated, age-normed and aligned to DSM-5 diagnostic criteria.
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Clear Clinical Reports

Instant reports with actionable insights to support diagnosis and drive care pathways and coordinated interventions.
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Designed for Primary Care Workflows

Works across team-based care models with EHR interoperability, no special training required, and remote testing ability.
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Backed by Decades of Scientific Research

Built on rigorous science—30 years of research, an 85,000 participant normative database, and validation in over 400 peer-reviewed studies.
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From Brain Injury to Mental Health:
Creyos Covers the Spectrum of Cognitive Function

Creyos equips neurologists with gamified digital task-based assessments that deliver precise cognitive health insights across a wide range of conditions—including mild cognitive impairment, traumatic brain injury, neurodegenerative diseases like dementia, and mental health disorders.

Concussion and TBI

Neurodegenerative Disease

Behavioral and Mental Health Conditions

Concussion

Concussion and Traumatic Brain Injury (TBI) 

Identify post-concussive cognitive impairment to guide safer return-to-activity decisions and care plans. Creyos includes validated digitized tests to assess processing speed, attention, and executive function after head injury.

  • Can inform OT support and help coordinated care teams determine treatment plans
  • Results mapped to specific cognitive domains and brain regions to help inform focused treatment
  • Provides a standardized, repeatable and comprehensive testing approach
A beautiful thing about objectively measuring cognition is that we can validate patient experiences. Brain injury is not always visible, so many patients feel like they have to prove their symptoms. The only way to do this used to be with subjective interviews. Now, using Creyos, we can demonstrate where impairment and improvement is happening.

Dr. Williams

Medical Director

Cedars Sinai Kerlan-Jobe Center for Sports Neurology

Keep Care In-Network and Coordinated

Creyos gives neurologists data comparable to a neuropsychological exam to make faster, more confident care decisions—reducing the need for unnecessary referrals and improving the quality of information shared when referrals for further neuropsychological tests are required.
  • Clarify care needs with objective, domain-level results to reduce unnecessary referrals.
  • Share reports easily with PCPs, specialists and patient family members to support coordinated care.
  • Guide next steps with built-in care plans that track progress and support families.
The result: better care coordination, less referral leakage, and a smoother patient journey.
Care Plan

Online Neuropsychological Evaluation That Works With Your Workflow

Creyos was designed to fit seamlessly into modern neurology workflows, replacing complexity with clarity—without sacrificing clinical rigor.
  • Web-based and device-agnostic—accessible in clinic or remotely
  • No specialized training required to administer
  • Instant scoring and clear reporting to support time-pressed clinical encounters
  • EHR integration with Epic, eClinicalWorks, athenahealth, AdvanceMD and others—streamlining documentation and reducing administrative overhead
Whether it’s a first visit or a regular check-in, Creyos works the way you do.
Workflow
We administer Creyos on tablets and relate the tasks to being like puzzle games that our patients have likely played before. Because the tasks are gamified, Creyos alleviates some of the technology anxiety that our older patients have.

Melissa Picchione

Medical Director

Yukon Neurology

Guide Better Care. Capture Risk. Unlock Reimbursement

Creyos supports both fee-for-service and value-based care models with assessments that align to CPT codes like 96138, 96132, and 99483.

It enables earlier detection, personalized treatment planning, and ongoing monitoring— including supporting GUIDE Model participation for accurate dementia-related documentation under CMS-HCC V28. For both improving outcomes and optimizing reimbursement, Creyos delivers measurable impact across a variety of care models.

Better Care

An Inclusive Testing Experience for Your Entire Patient Panel

Creyos delivers an inclusive testing experience for children and older adults alike. Assessments are brief, language-inclusive, and designed to accommodate varying literacy levels, motor skills, backgrounds, and abilities—ensuring accurate results across your entire patient panel.

Inclusive Testing Experience

Ready to See Creyos in Action? 

Efficient online neuropsychological testing starts here. Experience how Creyos empowers neurologists to evaluate cognitive health with ease and scientific credibility

Access neuropsychological tests in digital format

Enhance diagnosis of neurodegenerative and post-traumatic conditions

Deliver better, faster care with a comprehensive cognitive assessment platform you can trust

Bring next-generation neuropsychological testing into your neurology practice. 

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Creyos in Action

Questions About Creyos? We Have Answers.

What neuropsychological tests are Creyos tasks based on?

Creyos is grounded in classical neuropsychological testing paradigms, adapted for digital delivery to provide efficient and precise cognitive assessments. Developed by Professor Adrian Owen, PhD, OBE, FRS, FRSC, FCAHS, a renowned neuroscientist, the platform's tasks are based on well-established cognitive tests and have been validated through extensive research and clinical use.

The Creyos battery includes 12 tasks targeting key cognitive domains:​
  • Memory: Tasks like Spatial Span assess short term memory (based on the Corsi Block Tapping Task) and Number Ladder assess visuospatial working memory.
  • Reasoning: Tasks such as Odd One Out (inspired by the Cattell Culture Fair Intelligence Test) and Spatial Planning (a variant of the Tower of London Task) evaluate problem-solving and planning abilities.
  • Attention: Feature Match and Double Trouble tasks, the latter being a variant of the Stroop Task, measure attention and response inhibition.
  • Verbal Ability: Grammatical Reasoning and Digit Span tasks assess language comprehension and verbal working memory.
Each task is designed to be completed in 2–3 minutes, allowing for a comprehensive assessment using all 12 tasks that typically takes under 40 minutes to complete. The platform's digital nature facilitates easy administration and immediate scoring, with results compared against a normative database of over 85,000 individuals. 

In summary, Creyos offers a scientifically validated, efficient, and user-friendly approach to cognitive assessment, rooted in traditional neuropsychological testing methodologies. 

Who is in the Creyos normative database?

The Creyos normative database comprises data from over 85,000 research participants worldwide, making it one of the largest and most comprehensive cognitive assessment databases available. Initially developed through a large-scale public study published in Neuron, individuals completed a series of 12 online cognitive tasks designed to evaluate various aspects of human cognitive ability.​

The database includes more than 14 million task scores. Participants provided demographic information, including age and gender, allowing for the creation of normative comparisons across different age groups, starting from age 6 and up. Gender is also considered in comparative analyses, although it can be omitted to compare a patient to all genders within the same age group 

The resulting dataset is considered to represent a generally healthy population, although some health conditions not related to intellectual disability may be present in proportions similar to the general population.

In summary, the Creyos normative database is a robust, scientifically validated resource that enables healthcare providers to compare individual cognitive assessment results against a large, diverse, and well-characterized population. This facilitates accurate interpretation of cognitive performance across various demographic groups. 

Can Creyos be used with patients who have known learning disabilities?

Yes, Creyos can be used with patients who have known learning disabilities.

The platform is designed to be inclusive and accessible across a wide range of cognitive and functional capabilities. Tests are adaptive and brief, with simple instructions and intuitive interfaces that minimize reliance on language, literacy, or motor skills—making them suitable for individuals with learning differences.

Can Creyos be used in telehealth settings?

Yes, Creyos is fully compatible with telehealth. Patients can complete cognitive assessments remotely on any device—no special hardware required. The platform supports secure, scientifically validated testing and integrates seamlessly into virtual care workflows, making it ideal for remote monitoring, ongoing cognitive care, and expanding access for patients in rural or underserved areas.

How does Creyos compare to traditional forms of cognitive assessment, like the MoCA, MMSE, or Mini-Cog?

Creyos offers several advantages over traditional forms of assessment like the MoCA, MMSE, and Mini-Cog. While those tools are brief screeners that rely heavily on subjective scoring and clinician interpretation, Creyos provides objective, domain-specific results based on decades of neuroscience research and a normative database of over 85,000 healthy individuals. It makes it easier to identify impairments in individuals with borderline MoCA scores (23–25) Sternin et al. (2019). This makes it possible to categorize them as clearly impaired or unimpaired. 

Creyos also delivers more precise, quantifiable insights across key cognitive domains, helping providers detect subtle changes earlier and make more confident decisions (Brenkel et al. (2017)). Creyos is also fully digital, automatically scored, and easily administered in-clinic or via telehealth—streamlining workflow while improving accuracy and consistency.

How has Creyos been validated?

Creyos has been validated through over three decades of peer-reviewed research by leading cognitive neuroscientists. Researchers have published more than 400 scientific studies using the Creyos platform, demonstrating its accuracy, reliability, and sensitivity in measuring core cognitive functions. This extensive body of evidence, combined with the platform's robust normative database of 85,000 participants, confirms Creyos as a scientifically robust tool for assessing cognition across clinical and research settings. To learn more visit: https://creyos.com/research-studies